Every living being wants to be happy, and nobody wants to suffer. Since suffering isn’t a cause but is a result, avoiding detrimental situations won’t eliminate suffering. To eliminate suffering, we need to avoid the causes of suffering. And the causes of suffering are karma and the ensuing mental afflictions that are stored in the ground consciousness as habitual tendencies and that are repeated when causes and conditions prevail. It’s for this reason that the Buddha taught the First Noble Truth, which is: The truth of suffering is that which is to be known. He taught the Second Noble Truth, which is: The truth of the cause of suffering is that which is to be avoided. This means to say that suffering will not end as long as we haven’t abandoned our mental afflictions and given up non-virtuous activities.
— 3rd Jamgon Kongtrul Rinpoche